Retrospective cohort study reveals increased mortality and complications with postoperative delirium in older surgical patients, highlighting perioperative brain health as a key target.
In this national retrospective cohort study of more than 5.5 million hospitalizations, older individuals undergoing major noncardiac surgery who experienced postoperative delirium had 3.5-fold higher odds of death or major complications, 2.8-fold higher odds of death, and 4.0-fold higher odds of nonhome discharge. There was substantial variation in the hospital rate of postoperative delirium after accounting for patient risk, which suggests that this complication may be an appropriate target for hospital efforts to improve perioperative brain health, provided that delirium screening and coding accuracy are improved.
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Lander et al. (2025) studied this question.
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