January 1, 2010Thrombosis and Haemostasis
Serum albumin and risk of venous thromboembolism
Why the study?
Is a low serum albumin concentration associated with an increased risk of venous thromboembolism in the general population?
Population
20,700 participants from two large, prospective, population-based cohorts: the Atherosclerosis Risk in…
Comparison
Low serum albumin concentration vs Higher serum albumin concentration
Design
Cohort
Authors
Discussion
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Member takes
Implication
Low albumin modestly marks higher VTE risk in community cohorts; leaves open causality and utility for risk stratification.
Structured PICO
Is a low serum albumin concentration associated with an increased risk of venous thromboembolism in the general population?
P
Population
20,700 participants from two large, prospective, population-based cohorts: the Atherosclerosis Risk in Communities (ARIC) Study (n = 15,300) and the Cardiovascular Health Study (CHS) (n = 5,400).
I
Intervention
Low serum albumin concentration (evaluated per standard deviation lower, and below the fifth percentile)
C
Comparator
Higher serum albumin concentration (evaluated per standard deviation higher, and above the fifth percentile)
O
Outcome
Validated venous thromboembolism (VTE) occurrence during follow-uphard clinical
Low serum albumin serves as a modest marker for increased venous thromboembolism risk, likely reflecting an underlying hyperinflammatory or hypercoagulable state rather than a direct causal relationship.
Cite This Study
Lutsey et al. (2010) studied this question.