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December 13, 2008Proceedings of the National Academy of SciencesOpen Access

CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

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Authors

JYJianda YuanSGSacha GnjaticHLHao Li

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Yuan et al. (2008) studied this question.

synapsesocial.com/papers/69dd47b37808b00a4799c0bchttps://doi.org/10.1073/pnas.0810114105
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elucidating the Autoimmune and Antitumor Effector Mechanisms of a Treatment Based on Cytotoxic T Lymphocyte Antigen-4 Blockade in Combination with a B16 Melanoma Vaccine2001 · 311 citations
  2. 2CTLA-4: a negative regulator of autoimmune disease.1996 · 381 citations
  3. 3CTLA-4 ligation blocks CD28-dependent T cell activation.1996 · 806 citations
  4. 4CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.1995 · 2,251 citations
  5. 5Novel efficacy criteria for antitumor activity to immunotherapy using the example of ipilimumab, an anti-CTLA-4 monoclonal antibody2008 · 36 citations