In vitro study reveals hepatoprotective effects of diterpenes from Pinus massoniana in HepG2 cells, highlighting potential therapeutic applications for oxidative liver injury.
Three new diterpenes, named pinusins D-F (1-3), were isolated from the Chinese medicine "Pini Lignum Nodi" (the dried tuberculate or branched nodes of Pinus massoniana), along with twelve known diterpenes. The structures of these new compounds were determined using detailed spectroscopic methods and ECD calculations. Compounds 4-15 displayed moderate hepatoprotective activity against H₂O₂-induced oxidative damage in HepG2 cells, while compounds 5-15 exhibited markedly enhanced efficacy -surpassing that of bicyclol (positive control).
No takes yet. Share an insight, caveat, or question.
Chen et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: