Molecular analysis reveals frequent WIF-1 promoter hypermethylation in bladder tumors, indicating epigenetic activation of canonical Wnt/beta-catenin signaling in pathogenesis.
This is the first report showing that CpG hypermethylation of the Wif-1 promoter is a frequent event in bladder tumor and may contribute to pathogenesis of bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway. The present study elucidates novel pathways that are involved in the pathogenesis of bladder cancer.
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Urakami et al. (2006) studied this question.
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