What question did this study set out to answer?

To determine how symbiotic gut bacteria stimulate mucosal host defenses and identify the antimicrobial mechanism of the epithelial C-type lectin RegIIIgamma.

August 24, 2006ScienceOpen Access

Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin

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Authors

HCHeather L. CashSouthwestern Medical Center CWCecilia V. WhithamThe University of Texas Southwestern Medical Center CBCassie L. BehrendtThe University of Texas Southwestern Medical Center

Discussion

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Implication

Preclinical study demonstrates symbiotic bacteria trigger bactericidal lectin secretion in the mammalian gut, indicating an innate immune mechanism for host-microbe balance.

Key Points

To determine how symbiotic gut bacteria stimulate mucosal host defenses and identify the antimicrobial mechanism of the epithelial C-type lectin RegIIIgamma.
Colonized germ-free mice with symbiotic bacteria to evaluate induction of epithelial RegIIIgamma expression.
Assessed bacterial target binding and bactericidal mechanisms of mouse RegIIIgamma and its human ortholog HIP/PAP against bacterial peptidoglycan carbohydrate.
Microbial colonization of germ-free mice induced mucosal epithelial expression of the secreted C-type lectin RegIIIgamma.
RegIIIgamma and human HIP/PAP acted as directly bactericidal proteins that bound bacterial surfaces through specific interactions with peptidoglycan carbohydrate without requiring complement recruitment domains.

Cite This Study

Cash et al. (2006) studied this question.

synapsesocial.com/papers/69dd4b437808b00a4799c4f5 https://doi.org/10.1126/science.1127119

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August 24, 2006ScienceOpen Access

Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin

View Full Paper

Ask AI

Bookmark

Authors

HCHeather L. CashSouthwestern Medical Center CWCecilia V. WhithamThe University of Texas Southwestern Medical Center CBCassie L. BehrendtThe University of Texas Southwestern Medical Center

Discussion

Member takes

Implication

Preclinical study demonstrates symbiotic bacteria trigger bactericidal lectin secretion in the mammalian gut, indicating an innate immune mechanism for host-microbe balance.

Key Points

To determine how symbiotic gut bacteria stimulate mucosal host defenses and identify the antimicrobial mechanism of the epithelial C-type lectin RegIIIgamma.
Colonized germ-free mice with symbiotic bacteria to evaluate induction of epithelial RegIIIgamma expression.
Assessed bacterial target binding and bactericidal mechanisms of mouse RegIIIgamma and its human ortholog HIP/PAP against bacterial peptidoglycan carbohydrate.
Microbial colonization of germ-free mice induced mucosal epithelial expression of the secreted C-type lectin RegIIIgamma.
RegIIIgamma and human HIP/PAP acted as directly bactericidal proteins that bound bacterial surfaces through specific interactions with peptidoglycan carbohydrate without requiring complement recruitment domains.

Cite This Study

Cash et al. (2006) studied this question.

synapsesocial.com/papers/69dd4b437808b00a4799c4f5 https://doi.org/10.1126/science.1127119

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