Population
C(2)C(12) myotubes in vitro and fast- vs. slow-twitch skeletal muscles in vivo
Comparison
Expression of constitutively active FoxO1… vs Control conditions
Design
Preclinical
Authors
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Hypothesis-generating for myostatin regulation in muscle differentiation; leaves open validation in human cardiovascular models.
FoxO1 and SMAD transcription factors cooperatively regulate myostatin expression and control skeletal muscle cell growth and differentiation.
Allen et al. (2006) studied this question.
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