What question did this study set out to answer?

To determine whether hypothalamic AMP-activated protein kinase (AMPK) metabolically controls the timing of female puberty onset through the regulation of Kiss1 neurons.

October 22, 2018Proceedings of the National Academy of SciencesOpen Access

Metabolic regulation of female puberty via hypothalamic AMPK–kisspeptin signaling

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To determine whether hypothalamic AMP-activated protein kinase (AMPK) metabolically controls the timing of female puberty onset through the regulation of Kiss1 neurons.
Assessed hypothalamic phosphorylated AMPK levels and puberty timing in immature female rats exposed to subnutrition or central pharmacological AMPK activation.
Selectively expressed a constitutively active form of AMPK via virogenetic delivery into kisspeptin neurons within the hypothalamic arcuate nucleus.
Evaluated pubertal timing under chronic subnutrition in transgenic mice harboring a conditional ablation of the AMPKα1 subunit specifically in Kiss1-expressing cells.
Pubertal subnutrition elevated hypothalamic phosphorylated AMPK, and central pharmacological activation of AMPK substantially delayed puberty onset in immature female rats.
Selective overexpression of constitutively active AMPK in arcuate nucleus Kiss1 neurons decreased Kiss1 expression, suppressed luteinizing hormone release, and delayed puberty.
Conditional knockout of the AMPKα1 subunit in Kiss1 neurons largely prevented the delay in pubertal onset caused by chronic negative energy balance.

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Implication

Preclinical study demonstrates that hypothalamic AMPK activation delays puberty onset in female rodents, indicating that energy deficiency represses kisspeptin signaling to stall maturation.

Cite This Study

Roa et al. (2018) studied this question.

synapsesocial.com/papers/69dd4d030a7b4bc8c410146b https://doi.org/10.1073/pnas.1802053115

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Implication

Preclinical study demonstrates that hypothalamic AMPK activation delays puberty onset in female rodents, indicating that energy deficiency represses kisspeptin signaling to stall maturation.

Metabolic regulation of female puberty via hypothalamic AMPK–kisspeptin signaling

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Discussion

Implication

Cite This Study

Metabolic regulation of female puberty via hypothalamic AMPK–kisspeptin signaling

Key Points

Discussion

Implication

Cite This Study

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