Why the study?
Do anti-streptococcal antibodies cross-react with viral and cardiac antigens to cause cytotoxicity?
Population
Murine anti-streptococcal monoclonal antibodies, heart and fibroblast cell lines, and synthetic peptides
Design
Preclinical
Authors
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Cross-reactive anti-streptococcal antibodies may mediate cardiac cytotoxicity; hypothesis-generating in animals and leaves open human relevance.
Do anti-streptococcal antibodies cross-react with viral and cardiac antigens to cause cytotoxicity?
Antibodies against alpha-helical structures of bacterial and viral antigens can lead to cytotoxic reactions, providing a potential mechanistic explanation for the origin of autoimmune heart disease.
Cunningham et al. (1992) studied this question.
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