Does pulsed field ablation safely and effectively create chronic lesions in a porcine model?
Pulsed field ablation safely creates complete circumferential replacement fibrosis in a preclinical porcine model, supporting its evaluation in clinical trials.
PFA deliveries to the SVC, RAA, and RSPV resulted in complete circumferential replacement fibrosis at 4-week postablation with an excellent chronic myocardial and collateral tissue safety profile. This GLP study evaluated the safety and efficacy of a dosage range in preparation for a clinical trial and characterized the non-thermal nature of PFA.
Stewart et al. (Tue,) studied this question.