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May 14, 2024Frontiers in Molecular BiosciencesOpen Access

Circulating microRNAs as promising diagnostic biomarkers for hepatocellular carcinoma: a systematic review and meta-analysis

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Authors

EAErmiyas AlemayehuAFAlebachew FasilHEHussen Ebrahim

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Overview

Meta-analysis demonstrates high diagnostic accuracy of circulating microRNAs for hepatocellular carcinoma, suggesting potential as non-invasive biomarkers.

Key Points

  • To systematically evaluate the overall diagnostic accuracy of circulating microRNAs as non-invasive biomarkers for detecting hepatocellular carcinoma.
  • Searched PubMed, Scopus, Embase, Wiley Online Library, and ScienceDirect for articles published between 2018 and July 30, 2023 (PROSPERO CRD42023417494).
  • Analyzed pooled diagnostic parameters using a random-effects model, with heterogeneity assessed via Cochran-Q and I² tests.
  • Explored heterogeneity sources using subgroup analysis and meta-regression, and assessed publication bias via Deeks' funnel plot.
  • Analyzed 24 studies including 1,668 individuals with hepatocellular carcinoma and 1,236 healthy controls.
  • Circulating miRNAs showed a pooled sensitivity of 0.84 (95% CI: 0.80–0.88), specificity of 0.81 (95% CI: 0.77–0.84), and an AUC of 0.89 (95% CI: 0.86–0.91).
  • Pooled positive likelihood ratio was 4.36 (95% CI: 3.59–5.30), negative likelihood ratio was 0.19 (95% CI: 0.15–0.25), and diagnostic odds ratio was 22.47 (95% CI: 14.47–32.64), with superior accuracy in plasma samples, miRNA panels, and cohorts with N ≥ 100.

Cite This Study

Alemayehu et al. (2024) studied this question.

synapsesocial.com/papers/69dd4f097808b00a4799c92ehttps://doi.org/10.3389/fmolb.2024.1353547
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hepatocellular Carcinoma2019 · 4,746 citations
  2. 2Quantification of microRNA levels in plasma – Impact of preanalytical and analytical conditions2018 · 79 citations
  3. 3Implication of miR-122, miR-483, and miR-335 Expression Levels as Potential Signatures in HCV-Related Hepatocellular Carcinoma (HCC) in Egyptian Patients2022 · 14 citations
  4. 4Circulating microRNAs as Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma2019 · 144 citations
  5. 5EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma2012 · 5,245 citations