What question did this study set out to answer?

To review the mechanisms of human epidermal growth factor receptor activation in alveolar epithelial cells and propose a model for how receptor signaling regulates barrier permeability during acute lung injury.

June 7, 2012American Journal of Respiratory Cell and Molecular Biology

Human Epidermal Growth Factor Receptor Signaling in Acute Lung Injury

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To review the mechanisms of human epidermal growth factor receptor activation in alveolar epithelial cells and propose a model for how receptor signaling regulates barrier permeability during acute lung injury.
Synthesized molecular and physiological evidence on HER family tyrosine kinase receptor signaling during alveolar epithelial injury and repair.
Constructed a theoretical model detailing how HER-mediated signaling cascades alter epithelial permeability and lung tissue recovery.
HER family tyrosine kinase receptors activate in alveolar epithelial cells following acute lung injury and directly modulate cell-cell adhesion, cell migration, and barrier permeability.
Dysregulated HER signaling pathways influence the severity of pulmonary edema and govern whether the alveolar epithelium successfully repairs or sustains ongoing tissue damage.

Authors

JFJames H. FiniganMetroHealth GDGregory P. DowneyNational Jewish Health JKJeffrey A. KernNational Jewish Health

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Implication

Narrative review outlines HER family activation and epithelial barrier regulation in acute lung injury, suggesting therapeutic targets for restoring pulmonary barrier function.

Cite This Study

Finigan et al. (2012) studied this question.

synapsesocial.com/papers/69dd582827c48be1bb40d052 https://doi.org/10.1165/rcmb.2012-0100tr

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Implication

Narrative review outlines HER family activation and epithelial barrier regulation in acute lung injury, suggesting therapeutic targets for restoring pulmonary barrier function.

Human Epidermal Growth Factor Receptor Signaling in Acute Lung Injury

Key Points

Discussion

Implication

Cite This Study

Human Epidermal Growth Factor Receptor Signaling in Acute Lung Injury

Key Points

Discussion

Implication

Cite This Study

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