Low Penetrance in the Long-QT Syndrome
Why the study?
Should molecular screening be performed in family members of genotyped LQTS patients to identify silent gene carriers?
Population
Families with Long-QT Syndrome (LQTS)
Comparison
Molecular screening vs Clinical evaluation alone
Authors
Discussion
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Member takes
Implication
Clinical evaluation alone may miss silent LQTS carriers at risk; leaves open whether routine molecular screening improves family outcomes.
Structured PICO
Should molecular screening be performed in family members of genotyped LQTS patients to identify silent gene carriers?
P
Population
Families with Long-QT Syndrome (LQTS)
I
Intervention
Molecular screening
C
Comparator
Clinical evaluation alone
O
Outcome
Identification of silent gene carriers
Clinical evaluation alone is insufficient to exclude LQTS in family members of affected patients; molecular screening is recommended to identify silent gene carriers.
Cite This Study
Priori et al. (1999) studied this question.