Why the study?
Does 24-h Holter monitoring of QT interval variables improve diagnostic accuracy for long QT syndrome compared to resting ECG in chromosome 11-linked patients?
Population
50 individuals (25 untreated long QT patients linked to chromosome 11 and 25 age- and gender-matched controls)
Comparison
24-h Holter monitoring to assess QT interval… vs Standard 12-lead resting ECG (QTc interval)
Design
Case-control
Authors
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May improve LQTS diagnosis over QTc alone in chromosome 11-linked cases; leaves open prospective validation before clinical adoption.
Does 24-h Holter monitoring of QT interval variables improve diagnostic accuracy for long QT syndrome compared to resting ECG in chromosome 11-linked patients?
Incorporating QT interval rate-dependence from 24-hour Holter recordings significantly improves the diagnostic accuracy for chromosome 11-linked long QT syndrome compared to resting QTc alone.
Nathalie Neyroud (1998) studied this question.
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