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January 1, 1998Annals of Noninvasive Electrocardiology

Relation Between Autonomic Nerve Activity and QT Interval in Patients with Congenital Long QT Syndrome: Analysis Using 24‐Hour Holter ECG Monitoring

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Key result

In patients with long QT syndrome without recent syncope, the QT interval correlated positively with the RR interval (r2=0.76), similar to controls (r2=0.90).

Why the study?

Does autonomic nerve activity correlate with QT interval in patients with congenital long QT syndrome?

Population

7 patients with congenital long QT syndrome with no recent syncope, 3 LQTS patients with recent syncopal…

Comparison

24-hour Holter ECG monitoring with… vs Control subjects without QT prolongation

Design

Case-control

Follow-up

24 hours

Authors

MSMayumi ShimonoTohoku Medical and Pharmaceutical UniversityAFAkira FujikiHeart Rhythm SocietyHIHiroshi InoueKanazawa University

Discussion

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Implication

Preserved QT-RR coupling in stable LQTS supports intact autonomic regulation; leaves open its disruption during syncope.

Study Design

Type

Observational (n=19)

Structured PICO

Does autonomic nerve activity correlate with QT interval in patients with congenital long QT syndrome?

P
Population
19 subjects (7 with long QT syndrome without recent syncope, 9 controls, and 3 with recent syncope) analyzed using 24-hour Holter ECG monitoring.
E
Exposure
24-hour Holter ECG monitoring with autoregressive spectral analysis of heart rate variability (LF and HF components)
C
Comparator
Control subjects without QT prolongation
O
Outcome
Relation between autonomic nerve activity (spectral power of low and high frequency components) and QT intervalsurrogate

Main Result

Absolute Event Rate: 0.76% vs 0.9%

In patients with congenital long QT syndrome without recent syncope, QT interval regulation by autonomic tone and heart rate is similar to healthy controls, but this relationship is disrupted during syncopal episodes.

Cite This Study

Shimono et al. (1998) conducted an observational in Congenital Long QT Syndrome (n=19). Congenital Long QT Syndrome vs. Control subjects without QT prolongation was evaluated on Correlation between QT interval and RR interval (r2). In patients with long QT syndrome without recent syncope, the QT interval correlated positively with the RR interval (r2=0.76), similar to controls (r2=0.90).

synapsesocial.com/papers/6a903b44b7ca3a823c9090fahttps://doi.org/10.1111/j.1542-474x.1998.tb00024.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contribution of heart rate to QT interval shortening during exercise1983 · 77 citations
  2. 2The Measurement of the Q-T Interval of the Electrocardiogram1952 · 628 citations
  3. 3Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. A direct effect of acetylcholine in ventricular myocardium.1990 · 267 citations
  4. 4Vagus-Induced Changes in Ventricular Electrophysiology of the Dog Heart With and Without β-Blockade1981 · 20 citations
  5. 5Relation between ventricular repolarization duration and cardiac cycle length during 24-hour Holter recordings. Findings in normal patients and patients with long QT syndrome.1992 · 176 citations