Key result
Patients with long QT syndrome exhibited a decreased correlation between the Q-aT and RR intervals compared to controls (median r 0.87 vs 0.93; P=0.001) and a steeper Q-aT/RR slope.
Why the study?
Does the dynamic relationship between the Q-aT interval and heart rate differ between patients with long QT syndrome and control subjects during 24-hour Holter monitoring?
Population
10 patients with long QT syndrome and 11 control subjects
Comparison
24-hour Holter ECG monitoring with computer… vs 11 control subjects
Design
Case-control
Follow-up
24-hour
Authors
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Altered Q-aT/RR dynamics may reflect repolarization instability in long QT syndrome; hypothesis-generating for Holter-based assessment, pending prospective validation.
Case-Control (n=21)
Does the dynamic relationship between the Q-aT interval and heart rate differ between patients with long QT syndrome and control subjects during 24-hour Holter monitoring?
Absolute Event Rate: 0.87% vs 0.93%
p-value: p=0.001
Patients with long QT syndrome exhibit abnormal T wave morphology that affects the Q-aT interval, resulting in a decreased correlation and steeper slope between Q-aT and RR intervals compared to healthy controls.
Emori et al. (1995) conducted a case-control in Long QT syndrome (n=21). Long QT syndrome vs. Control subjects was evaluated on Correlation between Q-aT and RR interval (r value) (p=0.001). Patients with long QT syndrome exhibited a decreased correlation between the Q-aT and RR intervals compared to controls (median r 0.87 vs 0.93; P=0.001) and a steeper Q-aT/RR slope.
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