What does this research mean for the field?

Quantitative electrocardiographic measures of repolarization, such as T wave symmetry and heterogeneity, can independently differentiate patients with long QT syndrome from normal subjects with high accuracy, performing significantly better than QT duration alone. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1990Circulation

Long QT syndrome. New electrocardiographic characteristics.

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Why the study?

Do new quantitative electrocardiographic repolarization variables accurately identify patients with long QT syndrome?

Population

352 subjects, comprising 315 normal subjects and 37 patients with long QT syndrome, aged 17 to 60 years.

Comparison

Classification model using five new… vs Alternative classification model based on the…

Design

Case-control

Authors

JBJesaia BenhorinElectrophysiology MMM. MerriUniversity of Rochester MAMattia AlbertiInterventional Cardiology

Discussion

Member takes

Implication

May aid ECG detection of long QT syndrome; hypothesis-generating and requires prospective validation before clinical use.

Structured PICO

Do new quantitative electrocardiographic repolarization variables accurately identify patients with long QT syndrome?

Population

352 subjects, comprising 315 normal subjects and 37 patients with long QT syndrome (members of well-identified long QT syndrome families, QTc > 0.44 second, 27% symptomatic), aged 17 to 60 years.

Intervention

Classification model using five new electrocardiographic repolarization variables (early duration, rate, T wave symmetry, late phenomena, and heterogeneity) measured on digitized 12-lead electrocardiograms.

Comparator

Alternative classification model based on the early duration variable as a single predictor variable.

Outcome

Differentiation of patients with long QT syndrome from normal subjects (sensitivity and specificity).surrogate

A novel classification model using five quantitative ECG repolarization variables accurately differentiates patients with long QT syndrome from normal subjects.

Cite This Study

Benhorin et al. (1990) studied this question.

synapsesocial.com/papers/6a1769a41b114e5976b40586 https://doi.org/10.1161/01.cir.82.2.521

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Long QT syndrome. New electrocardiographic characteristics.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Long QT syndrome. New electrocardiographic characteristics.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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