Key result
Review outlines promising non-invasive electrophysiological markers for LQTS without visible QT prolongation.
Why the study?
Borderline QTc prolongation requires further investigation, but definitive genetic testing cannot be applied routinely to every patient due to availability, cost, or incomprehensive results.
What are the most promising non-invasive electrophysiological markers associated with Long QT syndrome?
What are the most promising non-invasive electrophysiological markers associated with Long QT syndrome?
This review highlights non-invasive electrophysiological markers that may aid in diagnosing Long QT syndrome when standard QTc prolongation is borderline or absent.
May aid Long QT diagnosis with normal QTc; leaves open prospective validation before clinical adoption.
Long QT syndrome (LQTS) is a life-threatening channelopathy, characterized by permanent or transient QT interval prolongation on the 12-lead electrocardiogram and syncope associated with malignant ventricular rhythm disturbances, particularly polymorphic ventricular tachycardia also known as torsade de pointes. Corrected QT (QTc) interval measurement remains the initial source of LQTS diagnosis in any patient, but the borderline QTc interval prolongation should induce further investigation. Genetic testing has the greatest value to provide definitive diagnosis in such situations, but it cant be applied to each patient routinely, putting aside that it can often be incomprehensive, costly or unavailable. The present review discusses the most promising non-invasive electrophysiological markers associated with Long QT syndrome, particularly in absence of visible QT interval prolongation and clinical manifestations.
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Av et al. (2022) conducted a review in Long QT syndrome. Non-invasive electrophysiological markers was evaluated. This review discusses the most promising non-invasive electrophysiological markers associated with Long QT syndrome, particularly in the absence of visible QT interval prolongation.
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