Key result
Provocative treadmill testing identified LQTS genotypes, with LQT1 patients showing marked QTc prolongation during exercise (65 ms) compared to LQT2 (3 ms) and LQTS-negative patients (5 ms; P<0.0001).
Why the study?
Does provocative exercise testing predict the presence and genotype of Long-QT Syndrome in patients with suspected LQTS?
Observational (n=159)
Does provocative exercise testing predict the presence and genotype of Long-QT Syndrome in patients with suspected LQTS?
p-value: p=<0.0001
Provocative exercise testing, including postural changes and QT hysteresis, can help predict the presence and specific genotype of Long-QT Syndrome, especially when resting ECGs are borderline.
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May aid LQTS diagnosis when ECGs are borderline; hypothesis-generating and requires prospective validation versus genetic testing.
Wong et al. (2010) conducted an observational in Suspected Long-QT Syndrome (LQTS) (n=159). Provocative treadmill testing vs. LQTS-negative control subjects was evaluated on QTc prolongation during exercise (p=<0.0001). Provocative treadmill testing identified LQTS genotypes, with LQT1 patients showing marked QTc prolongation during exercise (65 ms) compared to LQT2 (3 ms) and LQTS-negative patients (5 ms; P<0.0001).
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