Key result
Resting QTc averages ~74 ms longer in symptomatic LQT2, while post-exercise metrics distinguish symptomatic LQT1.
Why the study?
Congenital long-QT syndrome causes sudden cardiac death in young individuals, but risk stratification is challenging because individual arrhythmic risk varies pronouncedly even among carriers of the same variant.
Do genotype-specific ECG parameters at rest and post-exercise distinguish between symptomatic and asymptomatic patients with Long-QT Syndrome?
Population
Patients with long-QT syndrome
Comparison
Symptomatic vs asymptomatic patients across different genetic forms of LQTS
Authors
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May aid genotype-specific LQTS risk stratification; hypothesis-generating and requires prospective validation.
Observational (n=48)
Yes
Do genotype-specific ECG parameters at rest and post-exercise distinguish between symptomatic and asymptomatic patients with Long-QT Syndrome?
Absolute Event Rate: 493.4% vs 419.5%
p-value: p=0.004
Genotype-specific ECG parameters, such as post-exercise QTc and delta Tpeak/end for LQT1 and resting QTc for LQT2, can effectively distinguish between symptomatic and asymptomatic patients, improving risk stratification.
Rieder et al. (2022) conducted an observational in Long-QT Syndrome (n=48). ECG-based risk stratification vs. Asymptomatic patients was evaluated on QTc at rest in LQT2 patients (p=0.004). QTc at rest was significantly longer in symptomatic than asymptomatic LQT2 patients (493.4 vs 419.5 ms), while post-exercise QTc and delta Tpeak/end distinguished symptomatic LQT1 patients.
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