Observational cohort study reveals sociodemographic, clinical, and genetic associations with self-reported antidepressant response, suggesting patient reports capture valid clinical outcomes.
Self-reported antidepressant response in the UK Biobank is influenced by sociodemographic, clinical, and genetic factors, mirroring clinical response measures. While positive outcomes are more frequent than remission reported in clinical trials, these self-reports replicate known treatment associations, suggesting they capture meaningful aspects of antidepressant effectiveness from the patient's perspective.
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Kamp et al. (2025) studied this question.
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