Population
Outbred Swiss Webster mice latently infected with herpes simplex virus (HSV)
Design
Preclinical
Follow-up
Up to 24 hours posttreatment
Authors
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Offers rapid murine model for HSV reactivation mechanisms; leaves open human applicability.
Transient hyperthermia rapidly induces HSV reactivation in latently infected murine ganglionic neurons, providing a model for studying the molecular mechanisms of viral reactivation.
Sawtell et al. (1992) studied this question.
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