Why the study?
Does having a biological parent with heart failure increase the risk of developing heart failure?
Does having a biological parent with heart failure increase the risk of developing heart failure?
Having a biological parent with heart failure is a significant risk factor, highlighting the importance of genetic factors in HF pathogenesis.
May inform family history–based HF risk assessment; leaves open causal genetic mechanisms pending validation.
Heart failure in a biological parent is an HF risk factor that is worth clinical consideration. The increased heritability of HF suggests that genetic factors are important in HF pathogenesis.
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Lindgren et al. (2018) studied this question.