Why the study?
Does acute and chronic isoproterenol infusion provoke cardiac oxidative stress and remodeling in rats?
Does acute and chronic isoproterenol infusion provoke cardiac oxidative stress and remodeling in rats?
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Isoproterenol infusion in rats induces cardiac oxidative stress, leading to MAP kinase activation acutely and fibrotic remodeling chronically.
beta-Adrenoceptor stimulation provokes cardiac oxidative stress. In the acute phase of ISO infusion, ROS are important activators of cardiac MAP kinase cascades; while, in the chronic phase, ROS may participate in cardiac remodeling, especially in respect to wall stiffness, based on fibrogenesis.
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Zhang et al. (2004) studied this question.
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