Dissecting the earliest molecular drivers of heart failure with preserved ejection fraction through single-cell transcriptomics

Cristina Panico; Gianluigi Condorelli

doi:10.1093/cvr/cvag256

October 23, 2026Cardiovascular ResearchOpen Access

Dissecting the earliest molecular drivers of heart failure with preserved ejection fraction through single-cell transcriptomics

View Full Paper

Ask AI

Bookmark

Share

Key Points

To dissect and characterize the initial molecular mechanisms and cellular drivers that promote the development of heart failure with preserved ejection fraction (HFpEF).
Application of single-cell transcriptomics to analyze gene expression profiles across diverse cardiac cell types during early HFpEF pathogenesis.
Identifies early transcriptomic alterations and critical molecular pathways that trigger myocardial dysfunction and remodeling in HFpEF.
Delineates distinct cell-specific contributions and regulatory gene networks that initiate disease progression prior to overt clinical failure.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Reveals early cellular and transcriptomic drivers of heart failure with preserved ejection fraction, suggesting novel pathways for early diagnostic and therapeutic intervention.

Abstract

Cristina Panico, Gianluigi Condorelli; Dissecting the earliest molecular drivers of HFpEF through single-cell transcriptomics, Cardiovascular Research, , c

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Panico et al. (2026) studied this question.

synapsesocial.com/papers/6aee6bb371a7594806220a8c https://doi.org/10.1093/cvr/cvag256

View Full Paper

Ask AI

Bookmark

Share

Dissecting the earliest molecular drivers of heart failure with preserved ejection fraction through single-cell transcriptomics

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Dissecting the earliest molecular drivers of heart failure with preserved ejection fraction through single-cell transcriptomics

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading