Smad3 signaling exerts cell-type specific opposing functional effects in the healing infarcted myocardium.
Cell-specific Smad3 effects in post-MI healing should not alter practice; leaves open targeted translational validation.
In healing myocardial infarction, myofibroblast- and cardiomyocyte-specific activation of Smad3 has contrasting functional outcomes that may involve activation of an integrin/reactive oxygen axis.
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Kong et al. (2017) studied this question.
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