Über die Verrucarine und Roridine, eine Gruppe von cytostatisch hochwirksamen Antibiotica aus Myrothecium‐Arten

From cultures of Myrothecium verrucaria (Albertini et Schweinitz) Ditmar ex Fries and Myrothecium roridum Tode ex Fries ( Fungi imperfecti ) a group of 10 new metabolites has been isolated in pure crystalline form and characterized by analytical and spectroscopic data: Verrucarin A (C 27 H 34 O 9 ), B (C 27 H 32 O 9 ), C, D, E, F, G, and Roridin A (C 29 H 40–42 O 9 ), B (C 28 H 46 O?) and Roridin C. They are neutral lipophilic compounds. The main constituents, Verrucarin A and B and Roridin A, show in vitro antifungal and high cytostatic activity.