What question did this study set out to answer?

To examine the biophysical principles governing marginal protein stability and characterize the molecular adaptations enabling structural preservation in extreme physical and chemical environments.

December 1, 1991European Journal of BiochemistryOpen Access

Protein stability and molecular adaptation to extreme conditons

View Full Paper

Ask AI

Bookmark

Authors

RJRainer JaenickeUniversity of Regensburg

Discussion

Member takes

Implication

Review uncovers structural mechanisms of protein adaptation in extremophiles, highlighting that subtle local sequence alterations preserve functional conformation under harsh physical conditions.

Key Points

To examine the biophysical principles governing marginal protein stability and characterize the molecular adaptations enabling structural preservation in extreme physical and chemical environments.
Synthesized biophysical and structural evidence on protein stability differences between mesophilic and extremophilic organisms.
Evaluated molecular mechanisms facilitating adaptation across stressors including temperature, hydrostatic pressure, pH, and salinity.
Thermal stability is conferred by improved packing density and specific local interactions rather than broad architectural remodeling, requiring only minimal amino acid changes.
Halophilic adaptation depends on favoring acidic over basic residues and decreasing hydrophobicity to preserve hydration and structural integrity.
Defined structural thresholds limiting organismal viability, including polypeptide hydrolysis, solvent disruption of stabilizing noncovalent interactions, impaired folding, and metabolic pathway disruption.

Cite This Study

Rainer Jaenicke (1991) studied this question.

synapsesocial.com/papers/69dd5ec87808b00a4799d47e https://doi.org/10.1111/j.1432-1033.1991.tb16426.x

View Full Paper

Ask AI

Bookmark

Implication

Review uncovers structural mechanisms of protein adaptation in extremophiles, highlighting that subtle local sequence alterations preserve functional conformation under harsh physical conditions.

Protein stability and molecular adaptation to extreme conditons

Discussion

Member takes

Implication

Key Points

Cite This Study

Protein stability and molecular adaptation to extreme conditons

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider