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Determine the fundamental optical properties—absorption coefficient, scattering coefficient, and anisotropy factor—of circulating human blood across the 400 to 2500 nm spectral range under varying physiological conditions.

January 1, 1999Journal of Biomedical OpticsOpen Access

Optical Properties of Circulating Human Blood in the Wavelength Range 400–2500 nm

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Determine the fundamental optical properties—absorption coefficient, scattering coefficient, and anisotropy factor—of circulating human blood across the 400 to 2500 nm spectral range under varying physiological conditions.
Applied the integrating sphere technique combined with inverse Monte Carlo simulations to measure absorption (μa), scattering (μs), and the anisotropy factor (g) in circulating human blood.
Measured optical spectra from 400 to 2500 nm under controlled variations in haematocrit (up to 50%), oxygen saturation, osmolarity, and wall shear rate.
At 633 nm, blood with 10% haematocrit and 98% oxygen saturation showed a μa of 0.210 ± 0.002 mm⁻¹, a μs of 77.3 ± 0.5 mm⁻¹, and a g factor of 0.994 ± 0.001.
Increasing haematocrit to 50% caused a linear rise in absorption and reduced scattering, while variations in osmolarity and shear rate altered all three parameters, and oxygenation changes exclusively shifted absorption.
Across 400–2500 nm, blood absorption matched the profiles of haemoglobin and water, scattering decreased above 500 nm approximately as λ⁻¹.⁷, and the g factor consistently exceeded 0.9.

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Implication

Experimental study demonstrates how physiological parameters alter the optical absorption, scattering, and anisotropy of circulating human blood, highlighting mechanisms for laser diagnostics.

Cite This Study

Roggan et al. (1999) studied this question.

synapsesocial.com/papers/69dd5f073f27c4971e99b5a4 https://doi.org/10.1117/1.429919

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Implication

Experimental study demonstrates how physiological parameters alter the optical absorption, scattering, and anisotropy of circulating human blood, highlighting mechanisms for laser diagnostics.

Optical Properties of Circulating Human Blood in the Wavelength Range 400–2500 nm

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Implication

Cite This Study

Optical Properties of Circulating Human Blood in the Wavelength Range 400–2500 nm

Key Points

Discussion

Implication

Cite This Study

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