Are there genomic and clinical differences in EV-D68 infections between the 2018 and 2022 seasons associated with acute flaccid myelitis?
Genomic changes in EV-D68 may be associated with differences in clinical outcomes and the incidence of acute flaccid myelitis across different viral seasons.
Our results show significant differences in the clinical outcomes of EV-D68 infections in 2018 and 2022 and highlight a 2018 cluster of genomic changes associated with these differences. Seasonal viral genomic surveillance-with in vitro characterization of the significance of these changes to viral fitness, immune responses, and neuropathogenesis-should shed light on the viral determinants of AFM.
Fall et al. (Wed,) studied this question.