Dysregulated subcutaneous adipose tissue, characterized by hypertrophy, inflammation, and fibrosis, may be a major susceptibility factor for the development of type 2 diabetes in genetically predisposed healthy individuals.
May identify genetically at-risk patients for closer monitoring; leaves open whether adipose-targeted interventions prevent T2D.
Genetic predisposition for type 2 diabetes is associated with impaired insulin sensitivity, adipocyte hypertrophy and other markers of adipose tissue dysfunction. A dysregulated subcutaneous adipose tissue may be a major susceptibility factor for later development of type 2 diabetes.
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Henninger et al. (2014) studied this question.