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January 7, 2014Journal of Translational MedicineOpen Access

Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation

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Authors

MCMahmood S. ChoudheryUniversity of Health Sciences LahoreMBMichael BadowskiUniversity of ArizonaAMAngela MuiseUniversity of Arizona

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Implication

Experimental study demonstrates impaired expansion and differentiation in aged donor mesenchymal stem cells, suggesting challenges for autologous stem cell therapies.

Key Points

  • To assess how advancing donor age influences the proliferative expansion, multilineage differentiation, and functional efficacy of adipose tissue-derived mesenchymal stem cells.
  • Assessed adipose tissue-derived mesenchymal stem cells harvested across different donor age groups.
  • Evaluated in vitro cell expansion kinetics and differentiation potential in relation to advancing donor chronological age.
  • Advancing donor age leads to significant reductions in mesenchymal stem cell expansion capacity and multilineage differentiation potential.
  • Age-associated functional impairments negatively affect stem cell potency, presenting potential hurdles for clinical cell-based therapies.

Cite This Study

Choudhery et al. (2014) studied this question.

synapsesocial.com/papers/69dd608c7808b00a4799d501https://doi.org/10.1186/1479-5876-12-8
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