Why the study?
Do semi-automated late gadolinium enhancement quantification techniques provide accurate and reproducible LGE volume measurements compared to manual segmentation in patients with hypertrophic cardiomyopathy?
Do semi-automated late gadolinium enhancement quantification techniques provide accurate and reproducible LGE volume measurements compared to manual segmentation in patients with hypertrophic cardiomyopathy?
The STRM >3SD technique is the preferred semi-automated approach for LGE quantification in HCM patients due to its optimal balance of accuracy and reproducibility.
STRM >3SD may optimize LGE quantification in HCM; leaves open prospective outcome validation before practice change.
FWHM segmentation provides superior reproducibility, however systematically underestimates total LGE volume compared to manual segmentation in patients with HCM. The STRM >3SD technique provides the greatest accuracy while retaining acceptable reproducibility and may therefore be a preferred approach for LGE quantification in this population.
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Mikami et al. (2014) studied this question.
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