October 5, 2006Science
Activity- and mTOR-Dependent Suppression of Kv1.1 Channel mRNA Translation in Dendrites
Why the study?
Does mTOR or NMDA receptor inhibition increase local dendritic synthesis of Kv1.1 channels in hippocampal neurons?
Population
Hippocampal neurons
Comparison
Rapamycin or NMDA glutamate receptor inhibition vs Untreated control (implied)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports mTOR/NMDA regulation of dendritic Kv1.1 in rodents; leaves open translation to human excitability or disease.
Structured PICO
Does mTOR or NMDA receptor inhibition increase local dendritic synthesis of Kv1.1 channels in hippocampal neurons?
P
Population
Hippocampal neurons
I
Intervention
Rapamycin (mTOR inhibitor) or NMDA glutamate receptor inhibition
C
Comparator
Untreated control (implied)
O
Outcome
Kv1.1 voltage-gated potassium channel protein expression and local synthesis in dendritessurrogate
Synaptic excitation may cause local suppression of dendritic Kv1 channels by reducing their local synthesis via mTOR and NMDA receptor pathways.
Cite This Study
Raab‐Graham et al. (2006) studied this question.