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DMSO/SOCl 2 was found to be an effective system for the intramolecular cyclization of 2‐alkynylbenzoates or 2‐alkynylbenzoic acids, which can afford biologically interesting 4‐(methylthio)isochromenones through regioselective electrophilic 6‐endo‐dig cyclization. DMSO plays the roles of both solvent and sulfur source and can also be replaced with its deuterated counterpart [D 6 ]DMSO, enabling the incorporation of the SCD 3 moiety into the isochromenone skeleton.
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An et al. (2020) studied this question.
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