January 1, 2025Orthopaedic Journal of Sports Medicine14 citationsOpen Access

The Impact of Contemporary Glucagon-like Peptide-1 Receptor Agonists on the Onset, Severity, and Conversion to Arthroplasty in Hip and Knee Osteoarthritis

JPJoshua R. PortoUniversity School MLMonish S. LavuUniversity School CHChristian J. HechtNebraska Medical Center

Structured PICO

Does GLP-1-RA use affect the incidence of OA diagnosis and conversion to arthroplasty in patients with or without preexisting OA?

Population

Patients with preexisting osteoarthritis (OA) diagnosis and patients with no preexisting OA diagnosis

Intervention

Glucagon-like peptide-1 receptor agonists (GLP-1-RAs)

Outcome

Conversion to total joint arthroplasty (TJA) or total knee arthroplasty (TKA), and incidence of OA diagnosishard clinical

GLP-1-RAs may have direct disease-modifying effects in osteoarthritis independent of weight loss, though their effects may differ based on preexisting disease status.

Abstract

GLP-1-RAs may provide direct disease-modifying behaviors in patients with preexisting OA diagnosis, per a reduced risk of conversion to TJA not attributable to weight loss. Further investigation is also needed to elucidate the association between GLP-1-RA use and the increased incidence of OA diagnosis and conversion to TKA in patients with no preexisting OA diagnosis.

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Cite This Study

Porto et al. (Wed,) studied this question.

synapsesocial.com/papers/69dd68b1629747396240cf6c https://doi.org/https://doi.org/10.1177/23259671241297157

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