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May 17, 2018VaccineOpen Access

Safety, tolerability, acceptability and immunogenicity of an influenza vaccine delivered to human skin by a novel high-density microprojection array patch (Nanopatch™)

Germain J. P. Fernando Julian Hickling Cesar M. Jayashi Flores Paul Griffin Christopher D. Anderson S. Rachel Skinner Cristyn Davies Katey Witham Melinda J. Pryor Jesse Bodle Steve Rockman Ian H. Frazer Angus H. Forster

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Abstract

Influenza vaccination using the NP appeared to be safe, and acceptable in this first time in humans study, and induced similar immune responses to vaccination by IM injection.

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Cite This Study

Fernando et al. (2018) studied this question.

synapsesocial.com/papers/69dd797630fba8aacf40c70c https://doi.org/10.1016/j.vaccine.2018.05.053

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Engineering Microneedle Patches for Vaccination and Drug Delivery to SkinClinical Trial · 2017 · 442 citations
2The success of microneedle-mediated vaccine delivery into skinHuman Clinical Trial · 2016 · 143 citations
3Safety, acceptability and tolerability of uncoated and excipient-coated high density silicon micro-projection array patches in human subjectsClinical Trial · 2017 · 46 citations
4Potent Immunity to Low Doses of Influenza Vaccine by Probabilistic Guided Micro-Targeted Skin Delivery in a Mouse ModelOriginal Research · 2010 · 172 citations
5Inactivated poliovirus type 2 vaccine delivered to rat skin via high density microprojection array elicits potent neutralising antibody responsespreclinical · 2016 · 45 citations

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