AnxA1 promotes myocardial repair by stimulating cardiac macrophages to release VEGF-A and induce neovascularization.
AnxA1 has a direct action on cardiac macrophage polarization toward a pro-angiogenic, reparative phenotype. AnxA1 stimulated cardiac macrophages to release high amounts of VEGF-A, thus inducing neovascularization and cardiac repair.
Ferraro et al. (Sat,) studied this question.