Key result
AnxA1 promotes cardiac repair and neovascularization by driving pro-angiogenic macrophage polarization and VEGF-A release.
AnxA1 promotes myocardial repair by stimulating cardiac macrophages to release VEGF-A and induce neovascularization.
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Should not change practice; hypothesis-generating for AnxA1 in post-MI repair.
Ferraro et al. (2019) studied this question. AnxA1 promotes cardiac repair and neovascularization by stimulating cardiac macrophages to release VEGF-A and polarize toward a pro-angiogenic, reparative phenotype.
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