Population
Mouse peritoneal macrophages and macrophage-derived foam cells
Design
Preclinical
Authors
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May support anthocyanin atheroprotection via macrophage efflux; leaves open translation from this animal model.
Anthocyanins induce cholesterol efflux in mouse macrophages via the PPAR gamma-LXR alpha-ABCA1 signaling pathway, providing a molecular mechanism for their potential anti-atherosclerotic effects.
Xia et al. (2005) studied this question.
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