Key result
Multimodality imaging guides diagnosis of gestational trophoblastic neoplasia presenting with high β-hCG and intracardiac masses.
Why the study?
Gestational trophoblastic neoplasia with cardiac involvement is exceedingly rare and may mimic thrombus or primary cardiac tumor, complicating diagnosis.
Case Report (n=1)
Multimodality imaging is essential for diagnosing rare intracardiac metastases from gestational trophoblastic neoplasia, enabling prompt initiation of life-saving systemic chemotherapy.
Answers are grounded in this paper and cite their sources.
Highlights treatable etiology for intracardiac masses with elevated β-hCG; extends known cardiac manifestations of gestational trophoblastic neoplasia.
BACKGROUND: Gestational trophoblastic neoplasia (GTN) with cardiac involvement is exceedingly rare and may mimic thrombus or primary cardiac tumor, complicating diagnosis. CASE SUMMARY: A 28-year-old woman with a history of complete hydatidiform mole presented with acute cardiopulmonary symptoms, abdominal pain, and markedly elevated β-human chorionic gonadotropin (β-hCG) levels. Multimodality imaging revealed mobile left-sided intracardiac masses with pulmonary vein extension and metastatic renal lesions. Stage IV high-risk GTN was diagnosed without tissue biopsy, and multiagent chemotherapy was initiated, resulting in sustained β-hCG normalization and near-complete resolution of intracardiac masses on follow-up imaging. DISCUSSION: This case highlights the diagnostic challenges of cardiac involvement in GTN and underscores the importance of multimodality imaging in differentiating metastases from thrombus, enabling prompt initiation of life-saving systemic therapy. TAKE-HOME MESSAGES: GTN should be considered in patients with markedly elevated β-hCG and unexplained intracardiac masses. Multimodality imaging is essential to guide timely and appropriate diagnosis and management.
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Zárate-Correa et al. (2026) conducted a case report in Gestational Trophoblastic Neoplasia with Intracardiac Metastatic Masses (n=1). Multiagent chemotherapy was evaluated on β-hCG normalization and resolution of intracardiac masses. Multiagent chemotherapy resulted in sustained β-hCG normalization and near-complete resolution of intracardiac masses in a patient with Stage IV high-risk gestational trophoblastic neoplasia.
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