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April 14, 2026Frontiers in MedicineOpen Access

Ferroptosis in compromised bone healing after trauma: from the iron/ROS microenvironment to non-union and bone defect reconstruction

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Authors

COChaowei OuyangSichuan UniversityDZDi ZhangSichuan UniversityCLChangbin LeiSichuan University

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Implication

Narrative review outlines the role of ferroptosis in impaired bone healing, suggesting new therapeutic targets.

Key Points

  • To explore the role of ferroptosis in compromised bone healing and its implications for treatment.
  • Synthesize current evidence on ferroptosis and its biochemistry.
  • Characterize the post-traumatic microenvironment in relation to ferroptosis.
  • Review studies linking ferroptosis to clinical bone healing phenotypes.
  • Discuss therapeutic strategies targeting ferroptosis.
  • Ferroptosis is linked to impaired bone regeneration due to iron and ROS dynamics.
  • NCOA4-mediated ferritinophagy was identified as a key mechanism in certain phenotypes.
  • Macrophage ferroptosis was shown to suppress osteogenesis in infected bone defects.
  • Therapeutic strategies targeting ferroptosis showed potential in enhancing bone healing.

Cite This Study

Ouyang et al. (2026) studied this question.

synapsesocial.com/papers/69ddd8eee195c95cdefd6640https://doi.org/10.3389/fmed.2026.1803197
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