Key result
Severe and extreme hypertriglyceridemia linked to ~21% higher cardiovascular risk and more acute pancreatitis versus normal levels.
Why the study?
Severe hypertriglyceridemia has a causal role in acute pancreatitis, but the relationship between triglyceride levels and the risk of cardiovascular events is less well known.
Does severe or extreme hypertriglyceridemia increase the risk of acute pancreatitis and cardiovascular events in adults compared to normal triglyceride levels?
Cohort (n=134,116)
Does severe or extreme hypertriglyceridemia increase the risk of acute pancreatitis and cardiovascular events in adults compared to normal triglyceride levels?
Effect estimate: HR 2.586 (sHTG) and 4.695 (eHTG) for AP
p-value: p=<0.001
Severe and extreme hypertriglyceridemia are associated with a stepwise increased risk of acute pancreatitis and cardiovascular events compared to normal triglyceride levels.
Prompts closer monitoring for pancreatitis in sHTG and eHTG; reinforces real-world evidence of associated CV risk.
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Kessler et al. (2026) conducted a cohort in Severe or extreme hypertriglyceridemia (n=134,116). Severe and extreme hypertriglyceridemia vs. Normal triglyceride levels was evaluated on Incidence, adjusted risk, and adjusted odds of acute pancreatitis and cardiovascular events (HR 2.586 (sHTG) and 4.695 (eHTG) for AP, p=<0.001). Severe and extreme hypertriglyceridemia significantly increased the risk of acute pancreatitis (HR 2.586 and 4.695) and cardiovascular events (HR 1.163 and 1.206) compared to normal triglycerides.
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