Vascular compliance phenotyping in pulmonary arterial hypertension (a PVDOMICS study)

Q: What is the clinical evidence from this study?

Population: Pulmonary arterial hypertension.

Talitha G. Wilson; Laura Oppegard; Hongyang Pi; B. Houston; W.H. Wilson Tang; E M Horn; MONICA MUKHERJEE; Peter J. Leary; Jeff Robinson

doi:10.1016/j.jhlto.2026.100560

April 1, 2026JHLT OpenOpen Access

Vascular compliance phenotyping in pulmonary arterial hypertension (a PVDOMICS study)

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Key result

. No new claims.

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Key Points

The aim is to investigate the phenotyping of vascular compliance in patients with pulmonary arterial hypertension.
Utilized right heart catheterization to measure vascular parameters.
Employed cardiac magnetic resonance for cardiac assessment.
Conducted cardiopulmonary exercise testing for functional capacity.
Identified correlations between pulmonary arterial compliance and mean pulmonary artery pressure.
Demonstrated associations between pulmonary vascular resistance and vascular compliance phenotypes.

Structured PICO

P

Population

Patients with pulmonary arterial hypertension (PAH)

I

Intervention

Vascular compliance phenotyping

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Implication

Should not yet change clinical practice; leaves open vascular compliance role in PAH assessment pending validation.

Abstract

Hazard Ratio (HR) Pulmonary arterial hypertension (PAH) Right ventricle (RV) Pulmonary arterial compliance (PAC) Pulmonary vascular resistance (PVR) Pulmonary hypertension (PH) Resistance times compliance (RC) Mean pulmonary artery pressure (mPAP) University of Washington (UW) Stroke volume (SV) Pulmonary artery pulse pressure (PApp) Right heart catheterization (RHC) Cardiac magnetic resonance (CMR) Cardiopulmonary exercise testing (CPET) Diffusing capacity for carbon monoxide (DLCO) Pulmonary artery wedge pressures (PAWP) Idiopathic pulmonary arterial hypertension (IPAH) Familial pulmonary arterial hypertension (fPAH) Connective tissue disease associated pulmonary arterial hypertension (CTD-PAH) Interquartile range (IQR) Right atrial

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Cite This Study

Wilson et al. (2026) studied Pulmonary arterial hypertension. The abstract provides only a list of abbreviations related to pulmonary arterial hypertension and vascular compliance phenotyping, with no results or conclusions reported.

synapsesocial.com/papers/69ddd938e195c95cdefd67cb https://doi.org/10.1016/j.jhlto.2026.100560

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Vascular compliance phenotyping in pulmonary arterial hypertension (a PVDOMICS study)

Figures

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Vascular compliance phenotyping in pulmonary arterial hypertension (a PVDOMICS study)

Figures

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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