Abstract Objectives: This study evaluated the effectiveness of Computer-Aided Instruction (CAI) in improving Chemistry achievement compared with traditional teaching among first-year nursing students at Jose Rizal Memorial State University. Methods: A quasi-experimental pretest–posttest non-equivalent control group design was used involving 68 first-year nursing students (33 traditional, 35 CAI). A validated 60-item Chemistry test (KR-21 = 0.82) measured performance. The experimental group received multimedia-based CAI, while the control group received lecture-based instruction. Weighted mean summarized performance, t-test compared group differences and gain scores, and z-test assessed mastery against the 75% benchmark at α = 0.05. Findings: Both groups demonstrated comparable baseline knowledge, with no significant difference in pretest scores (t = 0.747 Novelty: This study demonstrates the existing body of research on the computer-aided instruction (CAI) by demonstrating not only significant achievement gains but also a measurable mastery-level attainment in sub-microscopic Chemistry concepts using a validated assessment framework and benchmark-based analysis. Unlike the prior studies that focus primarily on mean score differences, this research integrates the mastery thresholds, quasi-experimental validation, and gain score comparisons in providing stronger empirical evidence of instructional effectiveness in higher education. These findings contribute to the global discourse on technology-enhanced STEM education by offering a replicable instructional framework in addressing persistent conceptual difficulties in abstract scientific domains. Beyond its local context, the study provides transferable insights for institutions seeking scalable, multimedia-based strategies to improve conceptual mastery and academic performance in Chemistry and related science disciplines. Keywords: Computer-Assisted Instruction (CAI), Traditional Teaching Method, Chemistry Education, Science Learning Outcomes, Instructional Effectiveness
Chaudhari et al. (Sat,) studied this question.