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April 14, 2026Journal of Obstetrics Gynecology and Cancer Research0 citationsOpen Access

Single-Dose vs. Triple- dose Antibiotic Prophylaxis in Preventing Postoperative Infection in Elective Cesarean Section: A Randomized Controlled Trial

SMShohre Movahedi ZGZahra Ghalenoee MMMohammad Mirzaei

Key Points

The study aims to compare the effectiveness of single-dose versus triple-dose antibiotic prophylaxis in preventing postoperative infections after elective cesarean sections.
Double-blinded randomized clinical trial design
Participants: 120 pregnant women undergoing elective cesarean sections
Group 1: 2g Cefazolin as a single dose before surgery
Group 2: Cefazolin administered as single dose pre-surgery plus two doses post-surgery
Postoperative infection monitored at one week, two weeks, and one month post-operation
No statistically significant difference in cellulitis incidence (5% vs. 1.7%, P=0.238)
Adhesion rates were similar between groups (1.7% vs. 3.3%, P=0.559)
Purulent discharge occurred in 3.3% of one group compared to none in the other (P=0.238)
No cases of urine infection or postoperative fever reported in either group

Abstract

Background P=0.238), adhesion (1.7% vs. 3.3%, P=0.559, purulent discharge (3.3% vs 0%, P=0238) . No cases of urine infection and postoperative fever were reported in any of the two groups.Conclusion: Single-dose antibiotic prophylaxis using cefazolin has comparable efficacy to multi-dose antibiotic regimens and potentially offers a cost-effective advantage.

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