Why the study?
Historic names of mammalian GRKs were replaced by systematic ones in the 1990s, but both kinds of names remain in use for mammalian arrestins.
Design
Review
No immediate implications for clinical cardiology; extends the field by standardizing nomenclature for GRK and arrestin functions in GPCR signaling.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins. Here, we describe the history of the discovery of the members of these two protein families, their structure and GPCR‐dependent and ‐independent functions, as well as the origins of their historic names and the advantages of systematic nomenclature.
No takes yet. Share an insight, caveat, or question.
Vsevolod V. Gurevich (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: