Abstract: The advancement of topical pharmaceutical delivery systems has been significantly boosted by the development of polymer-based microsponge technologies. These microstructured, porous polymeric systems enable controlled, sustained, and site-specific release of active phar-maceutical ingredients (APIs), thereby enhancing therapeutic efficacy while reducing systemic side effects. Microsponge delivery systems encapsulate APIs within spherical polymer matrices that gradually release their contents upon dermal application. This controlled release mechanism has proven effective for a range of therapeutic agents, including anti-inflammatory, antifungal, and cosmetic actives. This review provides a comprehensive overview of recent innovations in polymeric microsponge systems for topical drug delivery. Emphasis is placed on critical formula-tion techniques such as solvent evaporation, quasi-emulsion solvent diffusion, and liquid-liquid suspension polymerization. The review also examines the biocompatibility, physicochemical sta-bility, and dermatological applicability of microsponge systems, supporting their integration into both pharmaceutical and cosmetic formulations. Furthermore, the role of nanotechnology in en-hancing microsponge performance is explored, particularly through nano-microsponge formula-tions that offer improved skin permeation and precise drug targeting. In summary, polymeric mi-crosponge technology represents a promising platform for topical drug delivery, with potential for significant clinical and commercial impact. Ongoing research in natural polymers, nanocarri-ers, and advanced formulation strategies is expected to expand the utility and effectiveness of these systems in the near future.
Kumar et al. (Wed,) studied this question.