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April 14, 2026Heart Rhythm3 citationsOpen Access

Cardiovascular-kidney-metabolic syndrome and atrial fibrillation: Insights from 2 real-world prospective registries across Europe and East Asia

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AAAmir AskarinejadTBTommaso BucciETEnrico Tartaglia

Key Result

High cardiovascular-kidney-metabolic risk is associated with an increased risk of all-cause death and major adverse cardiovascular events in patients with atrial fibrillation.

Key Points

  • To explore the relationship between cardiovascular-kidney-metabolic syndrome and atrial fibrillation and associated risks.
  • Analysis of two prospective registries
  • Focus on populations in Europe and East Asia
  • Assessment of all-cause death and MACE rates
  • High CKM risk correlates with increased all-cause mortality
  • Elevated risk of major adverse cardiovascular events (MACE) in high CKM patients
  • Recommendation for holistic care approaches to enhance patient outcomes

Structured PICO

Is high cardiovascular-kidney-metabolic (CKM) risk associated with an increased risk of all-cause death and MACE in patients with atrial fibrillation?

P
Population
Patients with atrial fibrillation from 2 real-world prospective registries across Europe and East Asia
O
Outcome
All-cause death and MACEhard clinical

High cardiovascular-kidney-metabolic risk in patients with atrial fibrillation is associated with increased mortality and MACE, highlighting the need for integrated care.

Abstract

High CKM risk was associated with an increased risk of all-cause death and MACE. A holistic or integrated care approach management strategy is recommended to improve clinical outcomes in these patients.

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Cite This Study

Askarinejad et al. (2026) studied this question. High cardiovascular-kidney-metabolic risk is associated with an increased risk of all-cause death and major adverse cardiovascular events in patients with atrial fibrillation.

synapsesocial.com/papers/69ddd9f9e195c95cdefd7763https://doi.org/10.1016/j.hrthm.2026.02.038
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