What question did this study set out to answer?

The aim is to develop a porous scaffold that mimics natural cancellous bone to enhance bone regeneration.

April 14, 2026Rare MetalsOpen Access

Cancellous Bone‐Like Sr‐Doped Hydroxyapatite/Gelatin Porous Scaffolds With Nanofibrous Architecture and Ion Release for Promoting Osteogenesis

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In vitro and in vivo studies show enhanced osteogenesis with a Sr-doped scaffold, suggesting its potential for bone repair.

The aim is to develop a porous scaffold that mimics natural cancellous bone to enhance bone regeneration.
Fabrication of SrHA/Gelatin scaffolds using thermally induced phase separation and paraffin sphere leaching.
Characterization of scaffold structure, including porosity and mechanical properties.
In vitro assessment of bone marrow mesenchymal stem cell behavior.
In vivo evaluation of trabecular bone formation in rat calvarial defects.
The SrHA/Gelatin scaffold significantly increased cell adhesion, proliferation, and migration compared to control scaffolds.
Expression of osteogenic genes was upregulated in response to the scaffold.
The scaffold facilitated robust bone formation and defect bridging in vivo, unlike limited repair in control groups.

Wang et al. (2026) studied this question.

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