Introduction:: The present study is directed towards determining and describing the development of the potential clinical application of liposomal nano-encapsulated Rosa damascena callus extract, specifically as a means to convey its properties for wound healing into the cosmetic field. Methods:: Using established methods, the synthesis process of the nanoparticles yielded an average diameter below 100 nm. This technology was selected because it can maintain the biological activity of the extract, optimise drug delivery using a controlled release technique, and enhance the antioxidant capacity of the encapsulated product. In vivo studies on two animal models were performed to evaluate the potential and safety of the nano-structured extract. Results:: The results showed significant improvement in wound healing compared to the marketed extract. Moreover, there were no cases of skin toxicity, irritation, or sensitivity in the treated material, reflecting the suitability of the formulation for topical administration. Discussion:: The in vitro results of this work support that these nano-formulations based on Rosa damascena callus extracts are potential new effective agents for tissue repair, particularly regarding their properties useful for wound healing. Conclusion:: This study provides an overview of the potential of lipid-based nano-encapsulation systems for plant extracts in the cosmetic field. The findings indicate that this technique can enhance the bioavailability and therapeutic efficacy of natural compounds. Future clinical applications in skin care and cosmetic products can now be envisaged.
Ghafarzadegan et al. (Wed,) studied this question.